Main Principles of Hair Loss Treatment
Visual image is of great importance in modern life as well as physical attractiveness and young appearance. Although hair loss doesn’t harm human health, it has negative impact on a person’s psychology and quality of life. Mainly women tend to have such reaction, though more and more men start to have it lately too. Male type baldness is comparatively normal physiological process and that’s why the majority of men get used to it, but some of them prefer active treatment. Some patients think that doctor doesn’t see their problem seriously, while sharing their hair loss problems with them. However it isn’t true, as far as hair loss influences a person’s quality of life, choosing effective treatment methods has a great importance. Individual approach of a doctor is also very important. Besides this, researching the hair loss causes is equally essential. Treatment requires complex approach.
Plasma therapy for non-cicatrical alopecia
Since 1970, plasma therapy has acquired an important role both in the process of tissue repair, hemostasis, and the acceleration of peptic ulcer diseases and regeneration processes. In recent years, plasma therapy has acquired a special role in the hair loss treatment algorithm.
During plasma therapy, platelet-rich plasma is used, which is rich in growth factor. The growth factor provides angiogenesis, extracellular matrix remodeling, cell proliferation and differentiation. Based on this, plasma therapy is used in many areas of medicine, such as: orthopedics, maxillofacial surgery, plastic surgery, dermatology.
Plasma that is used during plasma therapy is enriched with platelets (approximately 1 ml. Of platelets / μL). The regenerative property of plasma therapy depends on the level of released growth factor.
Platelet alpha granules contain a growth factor (GF), after activation of which they are responsible for initiating and maintaining a therapeutic effect. It is known that the composition of platelet-rich plasma, in addition to the growth factor, includes other protein molecules, such as: Adhesin, Chemokine, and other molecules that contribute to the processes of regeneration and proliferation.
Recently, many clinical studies on the effectiveness of plasma therapy during non-scar alopecia have been conducted. Of particular interest was the mechanism of the effect on the hair follicle of growth factors that make up the plasma.
Growth factors can be of several types:
Platelet growth factor (PDGF);
Transformation Growth Factor (TGF-b);
The growth factor of endothelin blood vessels (VEGF), which by their isomorphs bind to the corresponding receptors and ensure tissue angiogenesis.
They act on the stem cells from which epidermal cells and sebaceous glands of ectodermal origin are formed, found in the root of the hair follicle and on the papillary cells (dermal papilla) in the matrix, which leads us to stimulate hair growth, to activate the existing so-called. “Sleeping follicle.”
Plasma therapy is carried out 1 time per month.
It is desirable to conduct 9 procedures per year according to the appropriate scheme.
Before the procedure, it is desirable to conduct a general blood test, so that the trichologist will select a treatment regimen for you.
Mesotherapy has been in active usage in treatment and aesthetic medicine since 1952. This is when necessary medications are injected with micro injections and micro doses in or under the skin. The medication contains minerals, amino acids, vitamins and hyaluronic acid. As soon as the cocktail is injected, microcirculation starts improving, metabolism is activated, swelling is decreased, hyaluron and collagen production is increased. After these skin immune condition is improved and hair follicle is activated.
Mesotherapy is recommended in case of hair loss, aging skin changes, wrinkles, spots, gravitational phosphate, stretch marks and cellulite.
The procedure is conducted under local anesthesia, doesn’t require special preparation and has no age limitations.
Minoxidil Topical _ Piperidine Enamine was initially registered as a medication for hyperthony, though studies soon revealed that the patients taking these patients were prone to hair growth increase. This was the way how Minox Spray was invented, which was first registered in 1988 in the USA to treat androgenic alopecia in men and since 1991 it has been used in women as well.
Minoxidil sulphate – Minox active metabolite Expands blood vessels and finally leads to proliferation of follicles. It stimulates follicle growth being in catagen stage, prolongs anagen stage and accelerates the process of transforming from telogen to anagen.
Minoxidil is used twice a day on the damaged area, 1 ml/g should be equally applied onto the area.
In order to get the first result it should be used for 6 month. In case if the usage is stopped hair loss starts again after 8-12 weeks.
5 Alpha Reductase Inhibitors: finasteride and dutasteride
Finasteride is 5 alfa reductase inhibitor which was initially invented to treat benign hyperplasia of the prostate gland. It has been registered in Europe since 1992. Peroral form of the preparate decreases dehydrotestosterone level in serum and on the hairy area of scalp and doesn’t decrease testosterone and other hormones level in blood. It lessen hair loss intensiveness and helps new hairs to grow. The preparation is for long term usage. Finasteride 1 ml a day for androgenic alopecia was registered in 1998.
Clinical researches showed minor signs of sexual dysfunction, though after stopping finasteride usage the mentioned sings disappear.
- It is mainly used for alopecia areata, front fibrous alopecia, red flat lichen, pseudopelade, Lupus erythematosus. Topical Corticosteroids can be used in the forms of cream, lotion, foam, ointment or shampoo. The duration of its usage depends on the disease process. It should be prescribed by a doctor.
- Corticosteroid injection is used for alopecia areata, front fibrous alopecia, red flat lichen, pseudopelade, Lupus erythematosus and traction alopecia.
Generally Triamcinolone acetonide injections are used, concentration and the number of injections are decided by doctor.