Main Principles of Hair Loss Treatment

Visual image is of great importance in modern life as well as physical attractiveness and young appearance. Although hair loss doesn’t harm human health, it has negative impact on a person’s psychology and quality of life. Mainly women tend to have such reaction, though more and more men start to have it lately too. Male type baldness is comparatively normal physiological process and that’s why the majority of men get used to it, but some of them prefer active treatment. Some patients think that doctor doesn’t see their problem seriously, while sharing their hair loss problems with them. However it isn’t true, as far as hair loss influences a person’s quality of life, choosing effective treatment methods has a great importance. Individual approach of a doctor is also very important. Besides this, researching the hair loss causes is equally essential. Treatment requires complex approach.

Plasma therapy for non-cicatrical alopecia

Since 1970, plasma therapy has acquired an important role both in the process of tissue repair, hemostasis, and the acceleration of peptic ulcer diseases and regeneration processes. In recent years, plasma therapy has acquired a special role in the hair loss treatment algorithm.
During plasma therapy, platelet-rich plasma is used, which is rich in growth factor. The growth factor provides angiogenesis, extracellular matrix remodeling, cell proliferation and differentiation. Based on this, plasma therapy is used in many areas of medicine, such as: orthopedics, maxillofacial surgery, plastic surgery, dermatology.
Plasma that is used during plasma therapy is enriched with platelets (approximately 1 ml. Of platelets / μL). The regenerative property of plasma therapy depends on the level of released growth factor.
Platelet alpha granules contain a growth factor (GF), after activation of which they are responsible for initiating and maintaining a therapeutic effect. It is known that the composition of platelet-rich plasma, in addition to the growth factor, includes other protein molecules, such as: Adhesin, Chemokine, and other molecules that contribute to the processes of regeneration and proliferation.
Recently, many clinical studies on the effectiveness of plasma therapy during non-scar alopecia have been conducted. Of particular interest was the mechanism of the effect on the hair follicle of growth factors that make up the plasma.
Growth factors can be of several types:

Platelet growth factor (PDGF);

Transformation Growth Factor (TGF-b);

The growth factor of endothelin blood vessels (VEGF), which by their isomorphs bind to the corresponding receptors and ensure tissue angiogenesis.

They act on the stem cells from which epidermal cells and sebaceous glands of ectodermal origin are formed, found in the root of the hair follicle and on the papillary cells (dermal papilla) in the matrix, which leads us to stimulate hair growth, to activate the existing so-called. "Sleeping follicle."
Plasma therapy is carried out 1 time per month.
It is desirable to conduct 9 procedures per year according to the appropriate scheme.
Before the procedure, it is desirable to conduct a general blood test, so that the trichologist will select a treatment regimen for you.

 

Mesotherapy

Mesotherapy has been in active usage in treatment and aesthetic medicine since 1952. This is when necessary medications are injected with micro injections and micro doses in or under the skin. The medication contains minerals, amino acids, vitamins and hyaluronic acid. As soon as the cocktail is injected, microcirculation starts improving, metabolism is activated, swelling is decreased, hyaluron and collagen production is increased. After these skin immune condition is improved and hair follicle is activated.

Mesotherapy is recommended in case of hair loss, aging skin changes, wrinkles, spots, gravitational phosphate, stretch marks and cellulite.

The procedure is conducted under local anesthesia, doesn’t require special preparation and has no age limitations.

 

Low Level Laser Therapy (LLLT)

Low Level Laser Therapy is based on the joint impact of low level infrared rays and light rays on the cells, as a result of absorbing these energies renewing, regenerating process is activated in cells. It has been used in medicine since 1960 and the researches show that it has positive results in both men and women cases.

The procedure is short, simple and painless. In order to achieve perfect result approximately 26 weeks are necessary.

Minoxidil Topical

Minoxidil Topical _ Piperidine Enamine was initially registered as a medication for hyperthony, though studies soon revealed that the patients taking these patients were prone to hair growth increase. This was the way how Minox Spray was invented, which was first registered in 1988 in the USA to treat androgenic alopecia in men and since 1991 it has been used in women as well.

Minoxidil sulphate – Minox active metabolite Expands blood vessels and finally leads to proliferation of follicles. It stimulates follicle growth being in catagen stage, prolongs anagen stage and accelerates the process of transforming from telogen to anagen.

Minoxidil is used twice a day on the damaged area, 1 ml/g should be equally applied onto the area.

In order to get the first result it should be used for 6 month. In case if the usage is stopped hair loss starts again after 8-12 weeks.

5 Alpha Reductase Inhibitors: finasteride and dutasteride

Finasteride is 5 alfa reductase inhibitor which was initially invented to treat benign hyperplasia of the prostate gland. It has been registered in Europe since 1992. Peroral form of the preparate decreases dehydrotestosterone level in serum and on the hairy area of scalp and doesn’t decrease testosterone and other hormones level in blood. It lessen hair loss intensiveness and helps new hairs to grow. The preparation is for long term usage. Finasteride 1 ml a day for androgenic alopecia was registered in 1998.

Clinical researches showed minor signs of sexual dysfunction, though after stopping finasteride usage the mentioned sings disappear.

Topical Corticosteroids

  • It is mainly used for alopecia areata, front fibrous alopecia, red flat lichen, pseudopelade, Lupus erythematosus. Topical Corticosteroids can be used in the forms of cream, lotion, foam, ointment or shampoo. The duration of its usage depends on the disease process. It should be prescribed by a doctor.
  • Corticosteroid injection is used for alopecia areata, front fibrous alopecia, red flat lichen, pseudopelade, Lupus erythematosus and traction alopecia.

Generally Triamcinolone acetonide injections are used, concentration and the number of injections are decided by doctor.

Hair Filler

Hair filler is one of the new and innovative methods of stopping hair loss, when some micro injections are made on scalp which contain growing factor and biomimetic peptides including the most active 7 peptides for hair growth (Decapeptide-28, Oligopeptide-71,Octapeptide-2, Decapeptide-18, Oligopeptide-54, Octapeptide-11, Decapeptide-10). Eventually, microcirculation is activated, hair follicle is revitalized due to its size increase and hair loss is stopped.

The procedure is made with micro injections, totally 4 sessions are necessary with 2 weeks intervals.

Physiotherapeutic agents:

Darsonvalization is the use of high-frequency current pulses (110-400 kHz) and low power (0.01A) in the problem area. This method has been used in medicine for more than 100 years, in particular in dentistry, dermatology, neurology and gynecology.

As a result of the Darsonval procedures, blood circulation is activated, oxygen delivery to the cells is improved, fat metabolism is regulated, venous stasis is reduced, it has a bactericidal effect, it also enhances the nonspecific immunity of the skin, and accelerates regeneration processes.

As a result of all this, we obtain an improvement in elasticity and skin turgor, reduction of wrinkles, improvement in skin color and stimulation of hair growth.

The procedure is painless, is carried out in the form of one course (15-20 procedures).